A Brownian ratchet model for DNA loop extrusion by the cohesin complex

The cohesin complex topologically encircles DNA to promote sister chromatid cohesion. Alternatively, cohesin extrudes DNA loops, thought to reflect chromatin domain formation. Here, we propose a structure-based model explaining both activities. ATP and DNA binding promote cohesin conformational chan...

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Bibliografske podrobnosti
izdano v:eLife
Main Authors: Higashi, Torahiko L, Pobegalov, Georgii, Tang, Minzhe, Molodtsov, Maxim I, Uhlmann, Frank
Format: Artigo
Jezik:Inglês
Izdano: eLife Sciences Publications, Ltd 2021
Teme:
Chromosomes and Gene Expression
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8313234/
https://ncbi.nlm.nih.gov/pubmed/34309513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.67530
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