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Human cohesin compacts DNA by loop extrusion

Cohesin is a chromosome-bound multisubunit ATPase complex. Following its loading onto chromosomes, cohesin generates chromosome loops to regulate chromosome functions. It has been suggested that cohesin organizes the genome via loop extrusion, but direct evidence is lacking. Here, we use single-mole...

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Detalhes bibliográficos
Publicado no:Science
Main Authors: Kim, Yoori, Shi, Zhubing, Zhang, Hongshan, Finkelstein, Ilya J., Yu, Hongtao
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7387118/
https://ncbi.nlm.nih.gov/pubmed/31780627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaz4475
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