Efficient interspecies transmission of synthetic prions

Prions are comprised solely of PrP(Sc), the misfolded self-propagating conformation of the cellular protein, PrP(C). Synthetic prions are generated in vitro from minimal components and cause bona fide prion disease in animals. It is unknown, however, if synthetic prions can cross the species barrier...

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Dades bibliogràfiques
Publicat a:PLoS Pathog
Autors principals: Block, Alyssa J., Shikiya, Ronald A., Eckland, Thomas E., Kincaid, Anthony E., Walters, Ryan W., Ma, Jiyan, Bartz, Jason C.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2021
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8312972/
https://ncbi.nlm.nih.gov/pubmed/34260664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1009765
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