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Prion formation, but not clearance, is supported by protein misfolding cyclic amplification

Prion diseases are fatal transmissible neurodegenerative disorders that affect animals including humans. The kinetics of prion infectivity and PrP(Sc) accumulation can differ between prion strains and within a single strain in different tissues. The net accumulation of PrP(Sc) in animals is controll...

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Detalhes bibliográficos
Publicado no:Prion
Main Authors: Shikiya, Ronald A, Eckland, Thomas E, Young, Alan J, Bartz, Jason C
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4601219/
https://ncbi.nlm.nih.gov/pubmed/25482601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/19336896.2014.983759
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