Prion formation, but not clearance, is supported by protein misfolding cyclic amplification

Prion diseases are fatal transmissible neurodegenerative disorders that affect animals including humans. The kinetics of prion infectivity and PrP(Sc) accumulation can differ between prion strains and within a single strain in different tissues. The net accumulation of PrP(Sc) in animals is controll...

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Bibliographic Details
Published in:Prion
Main Authors: Shikiya, Ronald A, Eckland, Thomas E, Young, Alan J, Bartz, Jason C
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2014
Subjects:
Technical Report
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4601219/
https://ncbi.nlm.nih.gov/pubmed/25482601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/19336896.2014.983759
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