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Efficient interspecies transmission of synthetic prions

Prions are comprised solely of PrP(Sc), the misfolded self-propagating conformation of the cellular protein, PrP(C). Synthetic prions are generated in vitro from minimal components and cause bona fide prion disease in animals. It is unknown, however, if synthetic prions can cross the species barrier...

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Vydáno v:PLoS Pathog
Hlavní autoři: Block, Alyssa J., Shikiya, Ronald A., Eckland, Thomas E., Kincaid, Anthony E., Walters, Ryan W., Ma, Jiyan, Bartz, Jason C.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2021
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8312972/
https://ncbi.nlm.nih.gov/pubmed/34260664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1009765
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