CD14 inhibition improves survival and attenuates thrombo-inflammation and cardiopulmonary dysfunction in a baboon model of Escherichia coli sepsis

BACKGROUND: During sepsis, gram-negative bacteria induce robust inflammation primarily via lipopolysacharride (LPS) signaling through TLR4, a process that involves the glycosylphosphatidylinositol (GPI)-anchored receptor CD14 transferring LPS to the Toll-like receptor 4/myeloid differentiation facto...

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Veröffentlicht in:J Thromb Haemost
Hauptverfasser: Keshari, Ravi S., Silasi, Robert, Popescu, Narcis I., Regmi, Girija, Chaaban, Hala, Lambris, John D., Lupu, Cristina, Mollnes, Tom E., Lupu, Florea
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8312235/
https://ncbi.nlm.nih.gov/pubmed/33174372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.15162
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