Complement inhibition decreases the procoagulant response and confers organ protection in a baboon model of Escherichia coli sepsis

Severe sepsis leads to massive activation of coagulation and complement cascades that could contribute to multiple organ failure and death. To investigate the role of the complement and its crosstalk with the hemostatic system in the pathophysiology and therapeutics of sepsis, we have used a potent...

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Detalhes bibliográficos
Main Authors: Silasi-Mansat, Robert, Zhu, Hua, Popescu, Narcis I., Peer, Glenn, Sfyroera, Georgia, Magotti, Paola, Ivanciu, Lacramioara, Lupu, Cristina, Mollnes, Tom E., Taylor, Fletcher B., Kinasewitz, Gary, Lambris, John D., Lupu, Florea
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2010
Assuntos:
Thrombosis and Hemostasis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2924221/
https://ncbi.nlm.nih.gov/pubmed/20466856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-02-269746
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