Complement inhibition decreases the procoagulant response and confers organ protection in a baboon model of Escherichia coli sepsis

Severe sepsis leads to massive activation of coagulation and complement cascades that could contribute to multiple organ failure and death. To investigate the role of the complement and its crosstalk with the hemostatic system in the pathophysiology and therapeutics of sepsis, we have used a potent...

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Hlavní autoři: Silasi-Mansat, Robert, Zhu, Hua, Popescu, Narcis I., Peer, Glenn, Sfyroera, Georgia, Magotti, Paola, Ivanciu, Lacramioara, Lupu, Cristina, Mollnes, Tom E., Taylor, Fletcher B., Kinasewitz, Gary, Lambris, John D., Lupu, Florea
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2010
Témata:
Thrombosis and Hemostasis
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2924221/
https://ncbi.nlm.nih.gov/pubmed/20466856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-02-269746
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