Characterization and Functional Analysis of CD44v6.CAR T Cells Endowed with a New Low-Affinity Nerve Growth Factor Receptor-Based Spacer

Effectiveness of adoptively transferred chimeric antigen receptor (CAR) T cells strongly depends on the quality of CAR-mediated interaction of the effector cells with the target antigen on tumor cells. A major role in this interaction is played by the affinity of the single-chain variable fragment (...

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Detalhes bibliográficos
Publicado no:Hum Gene Ther
Main Authors: Stornaiuolo, Anna, Valentinis, Barbara, Sirini, Camilla, Scavullo, Cinzia, Asperti, Claudia, Zhou, Dan, Martinez De La Torre, Yeny, Corna, Stefano, Casucci, Monica, Porcellini, Simona, Traversari, Catia
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc., publishers 2021
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8312023/
https://ncbi.nlm.nih.gov/pubmed/33554732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2020.216
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