CAR T Cells Redirected to CD44v6 Control Tumor Growth in Lung and Ovary Adenocarcinoma Bearing Mice

The main challenge of adoptive therapy with Chimeric Antigen Receptor modified T cells (CAR T) is the application to the field of solid tumors, where the identification of a proper antigen has emerged as one of the major drawbacks to CAR T cell treatment success. CD44 is a glycoprotein involved in c...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Porcellini, Simona, Asperti, Claudia, Corna, Stefano, Cicoria, Eleonora, Valtolina, Veronica, Stornaiuolo, Anna, Valentinis, Barbara, Bordignon, Claudio, Traversari, Catia
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7010926/
https://ncbi.nlm.nih.gov/pubmed/32117253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.00099
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