Activation of the Protein Kinase R–Like Endoplasmic Reticulum Kinase (PERK) Pathway of the Unfolded Protein Response after Experimental Traumatic Brain Injury and Treatment with a PERK Inhibitor

Neurodegeneration after traumatic brain injury (TBI) is increasingly recognized as a key factor contributing to poor chronic outcomes. Activation (i.e., phosphorylation) of the protein kinase R-like endoplasmic reticulum kinase (PERK) pathway has been implicated in neurodegenerative conditions with...

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Dettagli Bibliografici
Pubblicato in:Neurotrauma Rep
Autori principali: Brady, Rhys D., Bird, Stefanie, Sun, Mujun, Yamakawa, Glenn R., Major, Brendan P., Mychasiuk, Richelle, O'Brien, Terence J., McDonald, Stuart J., Shultz, Sandy R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Mary Ann Liebert, Inc., publishers 2021
Soggetti:
Null Hypothesis
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8310749/
https://ncbi.nlm.nih.gov/pubmed/34318301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/neur.2021.0001
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