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On the mechanism of sensing unfolded protein in the endoplasmic reticulum
Unfolded proteins in the endoplasmic reticulum (ER) activate the ER transmembrane sensor Ire1 to trigger the unfolded protein response (UPR), a homeostatic signaling pathway that adjusts ER protein folding capacity according to need. Ire1 is a bifunctional enzyme, containing cytoplasmic kinase and R...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2005
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1316886/ https://ncbi.nlm.nih.gov/pubmed/16365312 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0509487102 |
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