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Distinct roles of activating transcription factor 6 (ATF6) and double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK) in transcription during the mammalian unfolded protein response.
In response to accumulation of unfolded proteins in the endoplasmic reticulum (ER), a homoeostatic response, termed the unfolded protein response (UPR), is activated in all eukaryotic cells. The UPR involves only transcriptional regulation in yeast, and approx. 6% of all yeast genes, encoding not on...
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Główni autorzy: | , , , , |
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Format: | Artigo |
Język: | Inglês |
Wydane: |
2002
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Hasła przedmiotowe: | |
Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1222788/ https://ncbi.nlm.nih.gov/pubmed/12014989 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20020391 |
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