Distinct roles of activating transcription factor 6 (ATF6) and double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK) in transcription during the mammalian unfolded protein response.

In response to accumulation of unfolded proteins in the endoplasmic reticulum (ER), a homoeostatic response, termed the unfolded protein response (UPR), is activated in all eukaryotic cells. The UPR involves only transcriptional regulation in yeast, and approx. 6% of all yeast genes, encoding not on...

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Bibliographic Details
Main Authors: Okada, Tetsuya, Yoshida, Hiderou, Akazawa, Rieko, Negishi, Manabu, Mori, Kazutoshi
Format: Artigo
Language:Inglês
Published: 2002
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1222788/
https://ncbi.nlm.nih.gov/pubmed/12014989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20020391
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