Plasmin-mediated cleavage of high-molecular-weight kininogen contributes to acetaminophen-induced acute liver failure

Acetaminophen (APAP)-induced liver injury is associated with activation of coagulation and fibrinolysis. In mice, both tissue factor–dependent thrombin generation and plasmin activity have been shown to promote liver injury after APAP overdose. However, the contribution of the contact and intrinsic...

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Vydáno v:Blood
Hlavní autoři: Henderson, Michael W., Sparkenbaugh, Erica M., Wang, Shaobin, Ilich, Anton, Noubouossie, Denis F., Mailer, Reiner, Renné, Thomas, Flick, Matthew J., Luyendyk, James P., Chen, Zu-Lin, Strickland, Sidney, Stravitz, R. Todd, McCrae, Keith R., Key, Nigel S., Pawlinski, Rafal
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2021
Témata:
Thrombosis and Hemostasis
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8310429/
https://ncbi.nlm.nih.gov/pubmed/33827130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020006198
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