Plasmin-mediated cleavage of high-molecular-weight kininogen contributes to acetaminophen-induced acute liver failure

Acetaminophen (APAP)-induced liver injury is associated with activation of coagulation and fibrinolysis. In mice, both tissue factor–dependent thrombin generation and plasmin activity have been shown to promote liver injury after APAP overdose. However, the contribution of the contact and intrinsic...

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Bibliografske podrobnosti
izdano v:Blood
Main Authors: Henderson, Michael W., Sparkenbaugh, Erica M., Wang, Shaobin, Ilich, Anton, Noubouossie, Denis F., Mailer, Reiner, Renné, Thomas, Flick, Matthew J., Luyendyk, James P., Chen, Zu-Lin, Strickland, Sidney, Stravitz, R. Todd, McCrae, Keith R., Key, Nigel S., Pawlinski, Rafal
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2021
Teme:
Thrombosis and Hemostasis
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8310429/
https://ncbi.nlm.nih.gov/pubmed/33827130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020006198
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