Plasmin-mediated cleavage of high-molecular-weight kininogen contributes to acetaminophen-induced acute liver failure

Acetaminophen (APAP)-induced liver injury is associated with activation of coagulation and fibrinolysis. In mice, both tissue factor–dependent thrombin generation and plasmin activity have been shown to promote liver injury after APAP overdose. However, the contribution of the contact and intrinsic...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Henderson, Michael W., Sparkenbaugh, Erica M., Wang, Shaobin, Ilich, Anton, Noubouossie, Denis F., Mailer, Reiner, Renné, Thomas, Flick, Matthew J., Luyendyk, James P., Chen, Zu-Lin, Strickland, Sidney, Stravitz, R. Todd, McCrae, Keith R., Key, Nigel S., Pawlinski, Rafal
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2021
Assuntos:
Thrombosis and Hemostasis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8310429/
https://ncbi.nlm.nih.gov/pubmed/33827130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020006198
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