Deletion of murine kininogen gene 1 (mKng1) causes loss of plasma kininogen and delays thrombosis

High-molecular-weight kininogen (HK) plays an important role in the assembly of the plasma kallikrein-kinin system. While the human genome contains a single copy of the kininogen gene, 3 copies exist in the rat (1 encoding K-kininogen and 2 encoding T-kininogen). Here, we confirm that the mouse geno...

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Bibliographic Details
Main Authors: Merkulov, Sergei, Zhang, Wan-Ming, Komar, Anton A., Schmaier, Alvin H., Barnes, Ellen, Zhou, Yihua, Lu, Xincheng, Iwaki, Takayuki, Castellino, Francis J., Luo, Guangbin, McCrae, Keith R.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2008
Subjects:
Hemostasis, Thrombosis, and Vascular Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2214772/
https://ncbi.nlm.nih.gov/pubmed/18000168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-06-092338
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