Red blood cell microvesicles activate the contact system, leading to factor IX activation via 2 independent pathways

Storage lesion–induced, red cell–derived microvesicles (RBC-MVs) propagate coagulation by supporting the assembly of the prothrombinase complex. It has also been reported that RBC-MVs initiate coagulation via the intrinsic pathway. To elucidate the mechanism(s) of RBC-MV–induced coagulation activati...

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Bibliographic Details
Published in:Blood
Main Authors: Noubouossie, Denis F., Henderson, Michael W., Mooberry, Micah, Ilich, Anton, Ellsworth, Patrick, Piegore, Mark, Skinner, Sarah C., Pawlinski, Rafal, Welsby, Ian, Renné, Thomas, Hoffman, Maureane, Monroe, Dougald M., Key, Nigel S.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2020
Subjects:
Thrombosis and Hemostasis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7059516/
https://ncbi.nlm.nih.gov/pubmed/31971571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019001643
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