Red blood cell microvesicles activate the contact system, leading to factor IX activation via 2 independent pathways

Storage lesion–induced, red cell–derived microvesicles (RBC-MVs) propagate coagulation by supporting the assembly of the prothrombinase complex. It has also been reported that RBC-MVs initiate coagulation via the intrinsic pathway. To elucidate the mechanism(s) of RBC-MV–induced coagulation activati...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Noubouossie, Denis F., Henderson, Michael W., Mooberry, Micah, Ilich, Anton, Ellsworth, Patrick, Piegore, Mark, Skinner, Sarah C., Pawlinski, Rafal, Welsby, Ian, Renné, Thomas, Hoffman, Maureane, Monroe, Dougald M., Key, Nigel S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2020
Assuntos:
Thrombosis and Hemostasis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7059516/
https://ncbi.nlm.nih.gov/pubmed/31971571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019001643
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