DCAF11 supports targeted protein degradation by electrophilic proteolysis-targeting chimeras

Ligand-induced protein degradation has emerged as a compelling approach to promote the targeted elimination of proteins from cells by directing these proteins to the ubiquitin-proteasome machinery. So far, only a limited number of E3 ligases have been found to support ligand-induced protein degradat...

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Publicado en:J Am Chem Soc
Main Authors: Zhang, Xiaoyu, Luukkonen, Lena M., Eissler, Christie L., Crowley, Vincent M., Yamashita, Yu, Schafroth, Michael A., Kikuchi, Shota, Weinstein, David S., Symons, Kent T., Nordin, Brian E., Rodriguez, Joe L., Wucherpfennig, Thomas G., Bauer, Ludwig, Dix, Melissa M., Stamos, Dean, Kinsella, Todd M., Simon, Gabriel M., Baltgalvis, Kristen A., Cravatt, Benjamin F.
Formato: Artigo
Idioma:Inglês
Publicado: 2021
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8309050/
https://ncbi.nlm.nih.gov/pubmed/33783207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.1c00990
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