DCAF11 supports targeted protein degradation by electrophilic proteolysis-targeting chimeras

Ligand-induced protein degradation has emerged as a compelling approach to promote the targeted elimination of proteins from cells by directing these proteins to the ubiquitin-proteasome machinery. So far, only a limited number of E3 ligases have been found to support ligand-induced protein degradat...

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Veröffentlicht in:J Am Chem Soc
Hauptverfasser: Zhang, Xiaoyu, Luukkonen, Lena M., Eissler, Christie L., Crowley, Vincent M., Yamashita, Yu, Schafroth, Michael A., Kikuchi, Shota, Weinstein, David S., Symons, Kent T., Nordin, Brian E., Rodriguez, Joe L., Wucherpfennig, Thomas G., Bauer, Ludwig, Dix, Melissa M., Stamos, Dean, Kinsella, Todd M., Simon, Gabriel M., Baltgalvis, Kristen A., Cravatt, Benjamin F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8309050/
https://ncbi.nlm.nih.gov/pubmed/33783207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.1c00990
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