Cholesterol is required for transcriptional repression by BASP1

Lipids are present within the cell nucleus, where they engage with factors involved in gene regulation. Cholesterol associates with chromatin in vivo and stimulates nucleosome packing in vitro, but its effects on specific transcriptional responses are not clear. Here, we show that the lipidated Wilm...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Loats, Amy E., Carrera, Samantha, Fleming, Anna F., Roberts, Abigail R. E., Sherrard, Alice, Toska, Eneda, Moorhouse, Alexander J., Medler, Kathryn F., Roberts, Stefan G. E.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2021
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8307447/
https://ncbi.nlm.nih.gov/pubmed/34266955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2101671118
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