Cholesterol is required for transcriptional repression by BASP1

Lipids are present within the cell nucleus, where they engage with factors involved in gene regulation. Cholesterol associates with chromatin in vivo and stimulates nucleosome packing in vitro, but its effects on specific transcriptional responses are not clear. Here, we show that the lipidated Wilm...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Loats, Amy E., Carrera, Samantha, Fleming, Anna F., Roberts, Abigail R. E., Sherrard, Alice, Toska, Eneda, Moorhouse, Alexander J., Medler, Kathryn F., Roberts, Stefan G. E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2021
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8307447/
https://ncbi.nlm.nih.gov/pubmed/34266955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2101671118
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