WWOX and Its Binding Proteins in Neurodegeneration

WW domain-containing oxidoreductase (WWOX) is known as one of the risk factors for Alzheimer’s disease (AD), a neurodegenerative disease. WWOX binds Tau via its C-terminal SDR domain and interacts with Tau phosphorylating enzymes ERK, JNK, and GSK-3β, and thereby limits AD progression. Loss of WWOX...

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Bibliographic Details
Published in:Cells
Main Authors: Hsu, Che-Yu, Lee, Kuan-Ting, Sun, Tzu-Yu, Sze, Chun-I., Huang, Shenq-Shyang, Hsu, Li-Jin, Chang, Nan-Shan
Format: Artigo
Language:Inglês
Published: MDPI 2021
Subjects:
Review
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8304785/
https://ncbi.nlm.nih.gov/pubmed/34359949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells10071781
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