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WWOX and Its Binding Proteins in Neurodegeneration
WW domain-containing oxidoreductase (WWOX) is known as one of the risk factors for Alzheimer’s disease (AD), a neurodegenerative disease. WWOX binds Tau via its C-terminal SDR domain and interacts with Tau phosphorylating enzymes ERK, JNK, and GSK-3β, and thereby limits AD progression. Loss of WWOX...
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| Vydáno v: | Cells |
|---|---|
| Hlavní autoři: | , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
MDPI
2021
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8304785/ https://ncbi.nlm.nih.gov/pubmed/34359949 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells10071781 |
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