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Induction of cryptic pre-mRNA splice-switching by antisense oligonucleotides

Antisense oligomers (AOs) are increasingly being used to modulate RNA splicing in live cells, both for research and for the development of therapeutics. While the most common intended effect of these AOs is to induce skipping of whole exons, rare examples are emerging of AOs that induce skipping of...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Ham, Kristin A., Keegan, Niall P., McIntosh, Craig S., Aung-Htut, May T., Zaw, Khine, Greer, Kane, Fletcher, Sue, Wilton, Steve D.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8302632/
https://ncbi.nlm.nih.gov/pubmed/34302060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-94639-x
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