Consequences of Making the Inactive Active Through Changes in Antisense Oligonucleotide Chemistries

Antisense oligonucleotides are short, single-stranded nucleic acid analogues that can interfere with pre-messenger RNA (pre-mRNA) processing and induce excision of a targeted exon from the mature transcript. When developing a panel of antisense oligonucleotides to skip every dystrophin exon, we foun...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Front Genet
Hauptverfasser: Zaw, Khine, Greer, Kane, Aung-Htut, May Thandar, Mitrpant, Chalermchai, Veedu, Rakesh N., Fletcher, Sue, Wilton, Steve D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2019
Schlagworte:
Genetics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6951410/
https://ncbi.nlm.nih.gov/pubmed/31956327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2019.01249
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