Identification of small molecules that mitigate vincristine‐induced neurotoxicity while sensitizing leukemia cells to vincristine

Vincristine (VCR) is one of the most widely prescribed medications for treating solid tumors and acute lymphoblastic leukemia (ALL) in children and adults. However, its major dose‐limiting toxicity is peripheral neuropathy that can disrupt curative therapy. Peripheral neuropathy can also persist int...

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Bibliografske podrobnosti
izdano v:Clin Transl Sci
Main Authors: Diouf, Barthelemy, Wing, Claudia, Panetta, John C., Eddins, Donnie, Lin, Wenwei, Yang, Wenjian, Fan, Yiping, Pei, Deqing, Cheng, Cheng, Delaney, Shannon M., Zhang, Wei, Bonten, Erik J., Crews, Kristine R., Paugh, Steven W., Li, Lie, Freeman, Burgess B., Autry, Robert J., Beard, Jordan A., Ferguson, Daniel C., Janke, Laura J., Ness, Kirsten K., Chen, Taosheng, Zakharenko, Stanislav S., Jeha, Sima, Pui, Ching‐Hon, Relling, Mary V., Eileen Dolan, M., Evans, William E.
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2021
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8301581/
https://ncbi.nlm.nih.gov/pubmed/33742760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cts.13012
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