Identification of small molecules that mitigate vincristine‐induced neurotoxicity while sensitizing leukemia cells to vincristine

Vincristine (VCR) is one of the most widely prescribed medications for treating solid tumors and acute lymphoblastic leukemia (ALL) in children and adults. However, its major dose‐limiting toxicity is peripheral neuropathy that can disrupt curative therapy. Peripheral neuropathy can also persist int...

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Publicat a:Clin Transl Sci
Autors principals: Diouf, Barthelemy, Wing, Claudia, Panetta, John C., Eddins, Donnie, Lin, Wenwei, Yang, Wenjian, Fan, Yiping, Pei, Deqing, Cheng, Cheng, Delaney, Shannon M., Zhang, Wei, Bonten, Erik J., Crews, Kristine R., Paugh, Steven W., Li, Lie, Freeman, Burgess B., Autry, Robert J., Beard, Jordan A., Ferguson, Daniel C., Janke, Laura J., Ness, Kirsten K., Chen, Taosheng, Zakharenko, Stanislav S., Jeha, Sima, Pui, Ching‐Hon, Relling, Mary V., Eileen Dolan, M., Evans, William E.
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2021
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8301581/
https://ncbi.nlm.nih.gov/pubmed/33742760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cts.13012
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