Identification of small molecules that mitigate vincristine‐induced neurotoxicity while sensitizing leukemia cells to vincristine

Vincristine (VCR) is one of the most widely prescribed medications for treating solid tumors and acute lymphoblastic leukemia (ALL) in children and adults. However, its major dose‐limiting toxicity is peripheral neuropathy that can disrupt curative therapy. Peripheral neuropathy can also persist int...

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Pubblicato in:Clin Transl Sci
Autori principali: Diouf, Barthelemy, Wing, Claudia, Panetta, John C., Eddins, Donnie, Lin, Wenwei, Yang, Wenjian, Fan, Yiping, Pei, Deqing, Cheng, Cheng, Delaney, Shannon M., Zhang, Wei, Bonten, Erik J., Crews, Kristine R., Paugh, Steven W., Li, Lie, Freeman, Burgess B., Autry, Robert J., Beard, Jordan A., Ferguson, Daniel C., Janke, Laura J., Ness, Kirsten K., Chen, Taosheng, Zakharenko, Stanislav S., Jeha, Sima, Pui, Ching‐Hon, Relling, Mary V., Eileen Dolan, M., Evans, William E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2021
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8301581/
https://ncbi.nlm.nih.gov/pubmed/33742760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cts.13012
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