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A Single Point Mutation Controls the Rate of Interconversion Between the g (+) and g (−) Rotamers of the Histidine 189 χ2 Angle That Activates Bacterial Enzyme I for Catalysis
Enzyme I (EI) of the bacterial phosphotransferase system (PTS) is a master regulator of bacterial metabolism and a promising target for development of a new class of broad-spectrum antibiotics. The catalytic activity of EI is mediated by several intradomain, interdomain, and intersubunit conformatio...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Front Mol Biosci |
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| Κύριοι συγγραφείς: | , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
Frontiers Media S.A.
2021
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8295985/ https://ncbi.nlm.nih.gov/pubmed/34307459 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2021.699203 |
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