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Active Site Breathing of Human Alkbh5 Revealed by Solution NMR and Accelerated Molecular Dynamics
AlkB homolog 5 (Alkbh5) is one of nine members of the AlkB family, which are nonheme Fe(2+)/α-ketoglutarate-dependent dioxygenases that catalyze the oxidative demethylation of modified nucleotides and amino acids. Alkbh5 is highly selective for the N(6)-methyladenosine modification, an epigenetic ma...
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| Publicat a: | Biophys J |
|---|---|
| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
The Biophysical Society
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6303414/ https://ncbi.nlm.nih.gov/pubmed/30352661 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2018.10.004 |
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