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Active Site Breathing of Human Alkbh5 Revealed by Solution NMR and Accelerated Molecular Dynamics

AlkB homolog 5 (Alkbh5) is one of nine members of the AlkB family, which are nonheme Fe(2+)/α-ketoglutarate-dependent dioxygenases that catalyze the oxidative demethylation of modified nucleotides and amino acids. Alkbh5 is highly selective for the N(6)-methyladenosine modification, an epigenetic ma...

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Dades bibliogràfiques
Publicat a:Biophys J
Autors principals: Purslow, Jeffrey A., Nguyen, Trang T., Egner, Timothy K., Dotas, Rochelle R., Khatiwada, Balabhadra, Venditti, Vincenzo
Format: Artigo
Idioma:Inglês
Publicat: The Biophysical Society 2018
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6303414/
https://ncbi.nlm.nih.gov/pubmed/30352661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2018.10.004
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