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N-terminal fusion of the N-terminal domain of bacterial Enzyme I facilitates recombinant expression and purification of the human RNA demethylases FTO and Alkbh5

Various fusion tags are commonly employed to increase the heterologous expression and solubility of aggregation-prone proteins within Escherichia coli. Herein, we present a protocol for efficient recombinant expression and purification of the human RNA demethylases Alkbh5 and FTO. Our method incorpo...

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Detalhes bibliográficos
Publicado no:Protein Expr Purif
Main Authors: Khatiwada, Balabhadra, Purslow, Jeffrey A., Underbakke, Eric S., Venditti, Vincenzo
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6942671/
https://ncbi.nlm.nih.gov/pubmed/31740367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pep.2019.105540
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