A Single Point Mutation Controls the Rate of Interconversion Between the g (+) and g (−) Rotamers of the Histidine 189 χ2 Angle That Activates Bacterial Enzyme I for Catalysis

Enzyme I (EI) of the bacterial phosphotransferase system (PTS) is a master regulator of bacterial metabolism and a promising target for development of a new class of broad-spectrum antibiotics. The catalytic activity of EI is mediated by several intradomain, interdomain, and intersubunit conformatio...

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Detalhes bibliográficos
Publicado no:Front Mol Biosci
Main Authors: Purslow, Jeffrey A., Thimmesch, Jolene N., Sivo, Valeria, Nguyen, Trang T., Khatiwada, Balabhadra, Dotas, Rochelle R., Venditti, Vincenzo
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Molecular Biosciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8295985/
https://ncbi.nlm.nih.gov/pubmed/34307459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2021.699203
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