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Conformationally Constrained Histidines in the Design of Peptidomimetics: Strategies for the χ-Space Control
A successful design of peptidomimetics must come to terms with χ-space control. The incorporation of χ-space constrained amino acids into bioactive peptides renders the χ(1) and χ(2) torsional angles of pharmacophore amino acids critical for activity and selectivity as with other relevant structural...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Molecular Diversity Preservation International (MDPI)
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3116161/ https://ncbi.nlm.nih.gov/pubmed/21686155 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms12052853 |
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