Synthesis and activity of endomorphin-2 and morphiceptin analogues with proline surrogates in position 2

The opioid agonists endomorphins (Tyr–Pro–Trp–Phe–NH(2); EM1 and Tyr–Pro–Phe–Phe–NH(2); EM2) and morphiceptin (Tyr–Pro–Phe–Pro–NH(2)) exhibit an extremely high selectivity for μ-opioid receptor. Here a series of novel EM2 and morphiceptin analogues containing in place of the proline at position 2 th...

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Publicado no:Eur J Med Chem
Main Authors: Giordano, Cesare, Sansone, Anna, Masi, Annalisa, Lucente, Gino, Punzi, Pasqualina, Mollica, Adriano, Pinnen, Francesco, Feliciani, Federica, Cacciatore, Ivana, Davis, Peg, Lai, Josephine, Ma, Shou-Wu, Porreca, Frank, Hruby, Victor
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5689459/
https://ncbi.nlm.nih.gov/pubmed/20692738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2010.07.022
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