Synthesis and evaluation of new endomorphin analogues modified at the Pro(2) residue

Six new endomorphin analogues, incorporating constrained amino acids in place of native proline have been synthesized. Residues of (S)-azetidine-2-carboxylic acid (Aze), 3,4-didehydro-(S)-proline (Δ(3)Pro), azetidine-3-carboxylic acid (3Aze) and didehydro-alanine (ΔAla) have been used to prepare [Δ(...

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Autores principales: Torino, Domenica, Mollica, Adriano, Pinnen, Francesco, Lucente, Gino, Feliciani, Federica, Davis, Peg, Lai, Josephine, Ma, Shou-Wu, Porreca, Frank, Hruby, Victor J.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2009
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2737817/
https://ncbi.nlm.nih.gov/pubmed/19560919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.06.008
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