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Biological Active Analogues of the Opioid Peptide Biphalin: Mixed α/β(3)-Peptides
Natural residues of the dimeric opioid peptide Biphalin were replaced by the corresponding homo-β(3) amino acids. The derivative 1 containing hβ(3) Phe in place of Phe showed good μ- and δ-receptor affinities ( [Formula: see text]) and antinociceptive activity in vivo together with an increased enzy...
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| Main Authors: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3942533/ https://ncbi.nlm.nih.gov/pubmed/23547584 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm301456c |
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