Biological Active Analogues of the Opioid Peptide Biphalin: Mixed α/β(3)-Peptides

Natural residues of the dimeric opioid peptide Biphalin were replaced by the corresponding homo-β(3) amino acids. The derivative 1 containing hβ(3) Phe in place of Phe showed good μ- and δ-receptor affinities ( [Formula: see text]) and antinociceptive activity in vivo together with an increased enzy...

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Hauptverfasser: Mollica, Adriano, Pinnen, Francesco, Costante, Roberto, Locatelli, Marcello, Stefanucci, Azzurra, Pieretti, Stefano, Davis, Peg, Lai, Josephine, Rankin, David, Porreca, Frank, Hruby, Victor J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3942533/
https://ncbi.nlm.nih.gov/pubmed/23547584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm301456c
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