Novel Cyclic Biphalin Analogue with Improved Antinociceptive Properties

[Image: see text] Two novel opioid analogues have been designed by substituting the native d-Ala residues in position 2,2′ of biphalin with two residues of d-penicillamine or l-penicillamine and by forming a disulfide bond between the thiol groups. The so-obtained compound 9 containing d-penicillami...

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Detalhes bibliográficos
Main Authors: Mollica, Adriano, Carotenuto, Alfonso, Novellino, Ettore, Limatola, Antonio, Costante, Roberto, Pinnen, Francesco, Stefanucci, Azzurra, Pieretti, Stefano, Borsodi, Anna, Samavati, Reza, Zador, Ferenc, Benyhe, Sándor, Davis, Peg, Porreca, Frank, Hruby, Victor J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4160744/
https://ncbi.nlm.nih.gov/pubmed/25221662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500241n
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