Cyclic Biphalin Analogues Incorporating a Xylene Bridge: Synthesis, Characterization, and Biological Profile

[Image: see text] In this work we enhanced the ring lipophilicity of biphalin introducing a xylene moiety, thus obtaining three cyclic regioisomers. Novel compounds have similar in vitro activity as the parent compound, but one of these (6a) shows a remarkable increase of in vivo antinociceptive eff...

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Detaylı Bibliyografya
Yayımlandı:ACS Med Chem Lett
Asıl Yazarlar: Stefanucci, Azzurra, Carotenuto, Alfonso, Macedonio, Giorgia, Novellino, Ettore, Pieretti, Stefano, Marzoli, Francesca, Szűcs, Edina, Erdei, Anna I., Zádor, Ferenc, Benyhe, Sándor, Mollica, Adriano
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Chemical Society 2017
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5554896/
https://ncbi.nlm.nih.gov/pubmed/28835802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00210
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