Discovery of Kynurenines Containing Oligopeptides as Potent Opioid Receptor Agonists

Kynurenine (kyn) and kynurenic acid (kyna) are well-defined metabolites of tryptophan catabolism collectively known as “kynurenines”, which exert regulatory functions in host-microbiome signaling, immune cell response, and neuronal excitability. Kynurenine containing peptides end...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Edina Szűcs, Azzurra Stefanucci, Marilisa Pia Dimmito, Ferenc Zádor, Stefano Pieretti, Gokhan Zengin, László Vécsei, Sándor Benyhe, Marianna Nalli, Adriano Mollica
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: MDPI AG 2020-02-01
Cyfres:Biomolecules
Pynciau:
peptides
kynurenines
binding affinity
μ-opioid receptor
pharmacophore
g-protein activation
Mynediad Ar-lein:https://www.mdpi.com/2218-273X/10/2/284
Tagiau: Ychwanegu Tag
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