Cryo-EM structure of the human ELMO1-DOCK5-Rac1 complex

The dedicator of cytokinesis (DOCK) family of guanine nucleotide exchange factors (GEFs) promotes cell motility, phagocytosis, and cancer metastasis through activation of Rho guanosine triphosphatases. Engulfment and cell motility (ELMO) proteins are binding partners of DOCK and regulate Rac activat...

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Dades bibliogràfiques
Publicat a:Sci Adv
Autors principals: Kukimoto-Niino, Mutsuko, Katsura, Kazushige, Kaushik, Rahul, Ehara, Haruhiko, Yokoyama, Takeshi, Uchikubo-Kamo, Tomomi, Nakagawa, Reiko, Mishima-Tsumagari, Chiemi, Yonemochi, Mayumi, Ikeda, Mariko, Hanada, Kazuharu, Zhang, Kam Y. J., Shirouzu, Mikako
Format: Artigo
Idioma:Inglês
Publicat: American Association for the Advancement of Science 2021
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8294757/
https://ncbi.nlm.nih.gov/pubmed/34290093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abg3147
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