Cryo-EM structure of the human ELMO1-DOCK5-Rac1 complex

The dedicator of cytokinesis (DOCK) family of guanine nucleotide exchange factors (GEFs) promotes cell motility, phagocytosis, and cancer metastasis through activation of Rho guanosine triphosphatases. Engulfment and cell motility (ELMO) proteins are binding partners of DOCK and regulate Rac activat...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Sci Adv
Egile Nagusiak: Kukimoto-Niino, Mutsuko, Katsura, Kazushige, Kaushik, Rahul, Ehara, Haruhiko, Yokoyama, Takeshi, Uchikubo-Kamo, Tomomi, Nakagawa, Reiko, Mishima-Tsumagari, Chiemi, Yonemochi, Mayumi, Ikeda, Mariko, Hanada, Kazuharu, Zhang, Kam Y. J., Shirouzu, Mikako
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Association for the Advancement of Science 2021
Gaiak:
Research Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC8294757/
https://ncbi.nlm.nih.gov/pubmed/34290093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abg3147
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