Structural basis for mutual relief of the Rac guanine nucleotide exchange factor DOCK2 and its partner ELMO1 from their autoinhibited forms

DOCK2, a hematopoietic cell-specific, atypical guanine nucleotide exchange factor, controls lymphocyte migration through ras-related C3 botulinum toxin substrate (Rac) activation. Dedicator of cytokinesis 2–engulfment and cell motility protein 1 (DOCK2•ELMO1) complex formation is required for DOCK2-...

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Hlavní autoři: Hanawa-Suetsugu, Kyoko, Kukimoto-Niino, Mutsuko, Mishima-Tsumagari, Chiemi, Akasaka, Ryogo, Ohsawa, Noboru, Sekine, Shun-ichi, Ito, Takuhiro, Tochio, Naoya, Koshiba, Seizo, Kigawa, Takanori, Terada, Takaho, Shirouzu, Mikako, Nishikimi, Akihiko, Uruno, Takehito, Katakai, Tomoya, Kinashi, Tatsuo, Kohda, Daisuke, Fukui, Yoshinori, Yokoyama, Shigeyuki
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2012
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3295310/
https://ncbi.nlm.nih.gov/pubmed/22331897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1113512109
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