Granzyme A Stimulates pDCs to Promote Adaptive Immunity via Induction of Type I IFN

Granzyme A (GzmA), together with perforin, are well-known for their cytotoxic activity against tumor or virus-infected cells. In addition to this cytotoxic function, GzmA stimulates several immune cell types and induces inflammation in the absence of perforin, however, its effect on the dendritic ce...

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Udgivet i:Front Immunol
Main Authors: Shimizu, Kanako, Yamasaki, Satoru, Sakurai, Maki, Yumoto, Noriko, Ikeda, Mariko, Mishima-Tsumagari, Chiemi, Kukimoto-Niino, Mutsuko, Watanabe, Takashi, Kawamura, Masami, Shirouzu, Mikako, Fujii, Shin-ichiro
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2019
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6606709/
https://ncbi.nlm.nih.gov/pubmed/31293597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.01450
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