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Polymorphisms in IRF7 reduce IFNα responses of pDCs to HIV-1
Recognition of HIV-1 ssRNA by TLR7 induces the production of the pro-inflammatory cytokines that may contribute to the systemic immune activation associated with HIV-1 disease progression. Here we describe a novel association between polymorphisms in IRF7, a master regulator of IFNα, and the ability...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3098498/ https://ncbi.nlm.nih.gov/pubmed/21297422 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAD.0b013e328343c186 |
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