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Polymorphisms in IRF7 reduce IFNα responses of pDCs to HIV-1

Recognition of HIV-1 ssRNA by TLR7 induces the production of the pro-inflammatory cytokines that may contribute to the systemic immune activation associated with HIV-1 disease progression. Here we describe a novel association between polymorphisms in IRF7, a master regulator of IFNα, and the ability...

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Autors principals: Chang, J. Judy, Lindsay, Robert J., Kulkarni, Smita, Lifson, Jeffrey D., Carrington, Mary, Altfeld, Marcus
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3098498/
https://ncbi.nlm.nih.gov/pubmed/21297422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAD.0b013e328343c186
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