Increased IFN-α-producing Plasmacytoid Dendritic Cells (pDCs) in Human Th1-mediated Type 1 Diabetes: pDCs Augment Th1 Responses through IFN-α Production()

Increasing evidence suggests that type 1 interferon (IFN-α/β) is associated with pathogenesis of Th1-mediated type 1 diabetes (T1D). A major source of IFNα/β is plasmacytoid dendritic cells (pDCs). In this study, we analyzed peripheral blood pDC numbers and functions in at-risk, new onset and establ...

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Veröffentlicht in:J Immunol
Hauptverfasser: Xia, Chang-Qing, Peng, Ruihua, Chernatynskaya, Anna V, Yuan, Lihui, Carter, Carolyn, Valentine, John, Sobel, Eric, Atkinson, Mark A, Clare-Salzler, Michael J
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4500116/
https://ncbi.nlm.nih.gov/pubmed/24973447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1303230
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