The TNFR1 Antagonist Atrosimab Is Therapeutic in Mouse Models of Acute and Chronic Inflammation

Therapeutics that block tumor necrosis factor (TNF), and thus activation of TNF receptor 1 (TNFR1) and TNFR2, are clinically used to treat inflammatory diseases such as rheumatoid arthritis, inflammatory bowel disease and psoriasis. However, TNFR1 and TNFR2 work antithetically to balance immune resp...

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Bibliografiske detaljer
Udgivet i:Front Immunol
Main Authors: Richter, Fabian, Williams, Sarah K., John, Katharina, Huber, Carina, Vaslin, Camille, Zanker, Henri, Fairless, Richard, Pichi, Kira, Marhenke, Silke, Vogel, Arndt, Dhaen, Marie-Ann, Herrmann, Stefanie, Herrmann, Andreas, Pfizenmaier, Klaus, Bantel, Heike, Diem, Ricarda, Kontermann, Roland E., Fischer, Roman
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8294390/
https://ncbi.nlm.nih.gov/pubmed/34305946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.705485
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