Anti-TNFR1 targeting in humanized mice ameliorates disease in a model of multiple sclerosis

Tumour necrosis factor (TNF) signalling is mediated via two receptors, TNF-receptor 1 (TNFR1) and TNF-receptor 2 (TNFR2), which work antithetically to balance CNS immune responses involved in autoimmune diseases such as multiple sclerosis. To determine the therapeutic potential of selectively inhibi...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Williams, Sarah K., Fairless, Richard, Maier, Olaf, Liermann, Patricia C., Pichi, Kira, Fischer, Roman, Eisel, Ulrich L. M., Kontermann, Roland, Herrmann, Andreas, Weksler, Babette, Romero, Nacho, Couraud, Pierre-Olivier, Pfizenmaier, Klaus, Diem, Ricarda
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6133964/
https://ncbi.nlm.nih.gov/pubmed/30206422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-31957-7
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