Cyclin D2 overexpression enhances the efficacy of human induced pluripotent stem cell-derived cardiomyocytes for myocardial repair in a swine model of myocardial infarction

BACKGROUND: Human-induced pluripotent stem cells (hiPSCs) with normal or upregulated levels of CCND2 expression were differentiated into cardiomyocytes (CCND2(WT)CMs or CCND2(OE)CMs, respectively) and injected into infarcted pig hearts. METHODS: Acute myocardial infarction (AMI) was induced via a 60...

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Dettagli Bibliografici
Pubblicato in:Circulation
Autori principali: Zhao, Meng, Nakada, Yuji, Wei, Yuhua, Bian, Weihua, Chu, Yuxin, Borovjagin, Anton V, Xie, Min, Zhu, Wuqiang, Nguyen, Thanh, Zhou, Yang, Serpooshan, Vahid, Walcott, Gregory P., Zhang, Jianyi
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8292228/
https://ncbi.nlm.nih.gov/pubmed/33951921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.120.049497
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