Large Cardiac-muscle Patches Engineered from Human Induced-pluripotent Stem-cell–derived Cardiac Cells Improve Recovery from Myocardial Infarction in Swine

BACKGROUND: Here, we generated human cardiac muscle patches (hCMPs) of clinically relevant dimensions (4 cm × 2 cm × 1.25 mm) by suspending cardiomyocytes, smooth-muscle cells, and endothelial cells that had been differentiated from human induced-pluripotent stem cells (hiPSCs) in a fibrin scaffold...

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Bibliografiska uppgifter
I publikationen:Circulation
Huvudupphovsmän: Gao, Ling, Gregorich, Zachery R., Zhu, Wuqiang, Mattapally, Saidulu, Oduk, Yasin, Lou, Xi, Kannappan, Ramaswamy, Borovjagin, Anton V, Walcott, Gregory P., Pollard, Andrew E., Fast, Vladimir G., Hu, Xinyang, Lloyd, Steven G., Ge, Ying, Zhang, Jianyi
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2017
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5903991/
https://ncbi.nlm.nih.gov/pubmed/29233823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.117.030785
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